Team Leader in Medicinal Chemistry

Ref: 3767

The Institute of Cancer Research


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Role Managed by:

Dr Goran Gregorovic

Head of Research

t: +44 (0) 20 7340 6202


Primary Practice Group: Higher Education and Research

Salary & Benefits: Competitive

Closing Date: 19/11/2018

The Institute of Cancer Research, London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. The ICR are world leaders in identifying cancer genes, discovering cancer drugs and developing precision radiotherapy. Together with its hospital partner The Royal Marsden NHS Foundation Trust, they are rated in the top four centres for cancer research and treatment worldwide. The ICR works closely with funding organisations including Cancer Research UK, Breast Cancer Now and the Wellcome Trust to deliver its programme of research.

The Cancer Research UK Cancer Therapeutics Unit (CTU) within Division of Cancer Therapeutics is ranked among the world’s best academic cancer drug discovery and development groups. Led by Professor Raj Chopra, CTU is a multidisciplinary 'bench to bedside' centre, comprising around 170 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. Its 12 research teams cover every aspect of new drug discovery and development, from cell and molecular biology through to chemical synthesis of new agents and their evaluation in clinical trials.

CRUK CTU now seeks to appoint a Team Leader in Medicinal Chemistry who will lead an independent chemistry research team that will contribute to the overall strategy and goals of the CTU. Reporting to the Unit Director Professor Raj Chopra and the Head of Chemistry Professor Ian Collins, the focus of the successful appointee will be on designing and synthesising compounds that meet the objectives of one or more of CTU’s drug discovery projects with the primary goal of optimisation and progression of innovative small molecules to proof-of-concept clinical trials. Commitment to translational and drug discovery research is fundamental to this position.

The successful candidate will be an established researcher with a strong background in medicinal chemistry and drug discovery with the demonstrable ability to develop a research programme aligned with the overall research strategy of CTU. With the opportunity to appoint a number of core-funded scientists to their team, s/he will have an international research reputation and the proven leadership skills to manage and mentor a multidisciplinary project team. Knowledge of cancer biology and a track record of innovation in drug discovery, chemical biology or new technologies are essential. S/he will have the drive and ability to publish high quality research in leading chemistry, medicinal chemistry, computational chemistry and/or chemical biology journals, and significant experience of successfully securing research funding in the academic or commercial sector.

For informal inquiries please contact Professor Ian Collins at the ICR at or +44 (0) 208 722 4317, or Dr Goran Gregorovic at or +44 20 7340 6202.

Applications should consist of a letter of motivation and a complete curriculum vitae including a publication and research funding list. The closing date for applications is Monday 19th November. Applications will be considered by the recruitment committee in late November and shortlisted candidates will subsequently be invited for campus visits and first stage interviews with representatives from the Division of Cancer Therapeutics in December. Final interviews will take place in early 2019.