Team Leader in In Vivo Biology

Ref: 5476

The Institute of Cancer Research


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Role Managed by:

Annabel Holt

Research Associate

t: +44 (0)20 7340 6219


Primary Practice Group: Higher Education and Research

Salary & Benefits: Competitive

Closing Date: 31/01/2022

Formal Interview Date: April 2022

The Institute of Cancer Research (ICR), London, is one of the world’s most influential cancer research institutes with an outstanding track record of achievement dating back more than 100 years. Our mission is to make the discoveries that defeat cancer, which we seek to achieve through world-leading research and internationally excellent learning and teaching.

Today, The ICR is rated as the UK’s leading higher education institution for the quality and impact of our research. We are world leaders in the identification of cancer-related genes, discovery of new targeted cancer drugs and development of new forms of high-precision radiotherapy. Our unique partnership with The Royal Marsden NHS Foundation Trust and integrated 'bench to bedside and back again’ approach ensure our research advances rapidly reach patients and place us among the top four centres in the world for cancer research and treatment.

The Division of Cancer Therapeutics has an unrivalled track record at discovering novel cancer treatments for the personalised treatment of cancer. The Division houses the Cancer Therapeutics Unit (CTU) as one of the largest academic cancer drug discovery groups in the world. With our collaborators, the CTU has discovered 20 preclinical development candidates since 2005, 11 of which have been progressed to clinical evaluation. Our drug abiraterone (Zytiga) has been approved in the US, Canada, and Europe for late-stage prostate cancer.

The ICR is now seeking a leading cancer biologist with a track record of success to lead the in vivo biology to support the drug discovery activities of the CTU.  The successful applicant will have the necessary scientific background and experience to hold the appropriate UK Home Office Project Licences. In addition, as a faculty member in the Division of Cancer Therapeutics, they will lead an independent cancer biology research group that will contribute to the overall strategy and goals of the Division and the CTU. As appropriate, the appointee will assume a leadership role for one or more drug discovery projects within the CTU portfolio.

The successful candidate will have extensive experience with a range of in vivo models (e.g. syngeneic, xenograft, orthotopic and metastatic tumours, patient-derived xenografts, genetically engineered animals), and will bring a strong vision for the future evolution of in vivo models. The appointee will be committed to translational and drug discovery research in the preclinical setting. Experience of drug discovery in a pharma or biotechnology company is desirable.

The ICR has engaged Perrett Laver to support the Appointment Panel for this role. For informal enquiries about the role please contact Annabel Holt at or +44 (0)20 7340 6219.

The closing date for applications is at 9am (GMT) on Monday 31st January 2022. Final stage interviews will take place in April 2022.


For a conversation in confidence, please contact Annabel Holt at or +44 (0)20 7340 6219.

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